In the Yo-Kai Watch media series, the story is told through the interactions and adventures of several human and Yo-Kai characters. The first of these characters to be featured is Keita Amano, who befriends the Yo-Kai Whisper during the first episode.
- Keita Amano (天野 景太) Nate Adams (English dub)
- Fumika Kodama (木霊 文花) Katie Forrester (English dub)
- Kanchi Imada (今田 干治) Eddie (English dub)
- Gorota Kumashima (熊島 五郎太) Bear (English dub)
- Keizō (ケイゾウ)
- Fumiaki (フミアキ)
- Inaho Misora (未空 イナホ)